Advances in Mimivirus Pathogenicity

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Advances in Mimivirus Pathogenicity

Viral diseases in the clinical setting have been extensively investigated. Viruses are now considered as potentially responsible for nosocomial infections, especially in intensive care unit (ICU) patients. Mimivirus is the largest virus known to date. Recent studies have suggested that Mimivirus could be responsible for both community-acquired and nosocomial pneumonia. These studies were mainly...

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Advances in Mimivirus Pathogenicity

Viral diseases in the clinical setting have been extensively investigated. Viruses are now considered as potentially responsible for nosocomial infections, especially in intensive care unit (ICU) patients. Mimivirus is the largest virus known to date. Recent studies have suggested that Mimivirus could be responsible for both community-acquired and nosocomial pneumonia. These studies were mainly...

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Mimivirus in Pneumonia Patients

Mimivirus, the largest virus known to date, is an amebal pathogen-like Legionella sp. When Mimivirus was used as an antigen in a microimmunofluorescense assay, seroconversion was found in patients with both community- and hospital-acquired pneumonia. Mimivirus DNA was found in respiratory samples of a patient with hospital-acquired pneumonia.

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PCR Detection of Mimivirus

T article by Zhang et al. (1) reporting the failure to detect mimivirus (Acanthamoeba polyphaga mimivirus) in patients with acute respiratory symptoms was flawed in 2 ways. First, a single mimivirus was detected by PCR but was dismissed by the authors as colonization. Second, and of greater concern, the PCR used by the authors would not detect most known mimiviruses because of primer/probe mism...

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O-Linked glycosylation in Acanthamoeba polyphaga mimivirus.

Acanthamoeba polyphaga mimivirus is a member of the giant nucleocytoplasmic large DNA viruses, infecting various Acanthamoeba spp. The genomes of giant viruses encode components previously thought to be exclusive to cellular life, such as proteins involved in nucleic acid and protein synthesis. Recent work on enzymes involved in carbohydrate biosynthesis and metabolism show that instead of util...

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ژورنال

عنوان ژورنال: Intervirology

سال: 2010

ISSN: 1423-0100,0300-5526

DOI: 10.1159/000312915